Medications for Hypothyroidism

 

Medications for Hypothyroidism

 

Some of the Patient Information Leaflets (PIL’s) have been obtained from the MHRA website: https://tinyurl.com/vwh739r

NB: Drugs can be manufactured by one company but distributed by another company, which means the name on the package might not be the same as the PIL information. The information below will state when a medication is the same product from different companies (e.g. Northstar distribute a Teva 25mcg tablet and Accord own Actavis and Almus). This can be confusing but if you note down the ingredients for the product that suits you, you will always know which generic (non-branded) is best for you.

 

 Levothyroxine

 

Product Name Eltroxin (Advanz) – 25mcg, 50mcg, 100mcg Tablets
Email medicalinformation@advanzpharma.com
Ingredients Anhydrous levothyroxine sodium, sodium citrate, lactose, maize starch, powdered acacia, magnesium stearate
PIL 25mcg: https://tinyurl.com/svyqwcs
50 & 100 mcg: https://tinyurl.com/wvydd3y

  

Product Name Levothyroxine (Advanz) –  25mcg, 50mcg, 100mcg Tablets
Email medicalinformation@advanzpharma.com
Ingredients Anhydrous levothyroxine sodium, sodium citrate, lactose, maize starch, powdered acacia, magnesium stearate
PIL 25mcg: https://tinyurl.com/svyqwcs
50 & 100mcg: https://tinyurl.com/wyym2kg

 

Product Name Levothyroxine (Actavis/Accord) – 50mcg, 100mcg Tablets
Email medinfo@accord-healthcare.com
Ingredients Anhydrous levothyroxine sodium, lactose, magnesium stearate, maize starch, pregelatinised maize starch, stearic acid
Comments Exactly the same product as Almus and Northstar generic licence tablet numbers: 50mcg: 0142/0104 and 100mcg: 0142/0105
PIL https://www.medicines.org.uk/emc/files/pil.5805.pdf

  

Product Name Levothyroxine (Almus/Accord) – 50mcg, 100mcg Tablets
Email medinfo@accord-healthcare.com
Ingredients Anhydrous levothyroxine sodium, lactose, magnesium stearate, maize starch, pregelatinised maize starch, stearic acid
Comments Exactly same product as Actavis and Northstar 50mcg &100mcg
PIL https://www.medicines.org.uk/emc/files/pil.5805.pdf

  

Product Name Levothyroxine (Northstar/Accord) – 50mcg, 100mcg Tablets
Email medinfo@accord-healthcare.com
Ingredients Anhydrous levothyroxine sodium, lactose, magnesium stearate, maize starch, stearic acid, pregelatinised maize starch
Comments Exactly same product as Actavis and Almus 50mcg & 100mcg
PIL https://www.medicines.org.uk/emc/files/pil.5805.pdf

 

Product Name Levothyroxine (Northstar/Teva) – 25mcg Tablets
Email medinfo@tevauk.com
Ingredients Levothyroxine sodium, maize starch, mannitol (E421), microcrystalline cellulose, sodium citrate, acacia, magnesium stearate
Comments Exactly same product as Teva 25mcg
PIL https://tinyurl.com/upaejp3

  

Product Name Levothyroxine (Teva) – 12.5mcg, 25mcg 50mcg, 75mcg, 100mcg Tablets (Lactose Free)
Email medinfo@tevauk.com
Ingredients Levothyroxine sodium, maize starch, mannitol (E421), micro-crystalline cellulose, sodium citrate, acacia, magnesium stearate
Comments 25mcg is exactly same product as Northstar 25mcg
PIL https://tinyurl.com/upaejp3

  

Product Name Levothyroxine (Wockhardt) – 25mcg Tablets
Email Drug.Safety@wockhardt.co.uk
Ingredients Levothyroxine sodium, lactose, sucrose (fine powder), maize starch, magnesium stearate
PIL https://tinyurl.com/vaw45wc

  

Product Name Levothyroxine (Aristo) – 100mcg Tablets (Lactose Free)
Email info@aristo-pharma.de
Ingredients Anhydrous levothyroxine sodium, microcrystalline cellulose, maize starch, heavy magnesium oxide, sodium starch glycolate type A, magnesium stearate
PIL https://tinyurl.com/wyhg8pr

  

Levothyroxine Oral Solutions

 

Product Name Eltroxin Oral Solution (Advanz) – 25mcg, 50mcg, 100mcg per 5ml (Lactose Free)
Email medicalinformation@advanzpharma.com
Website https://www.advanzpharma.com/
Ingredients Levothyroxine sodium (each 5ml of oral solution contains levothyroxine equivalent to levothyroxine sodium anhydrous 25mcg, 50mcg or 100mcg) glycerol, citric acid monohydrate, sodium methyl parahydroxybenzoate (E219), sodium hydroxide, purified water
PIL https://tinyurl.com/wk4x8uw

  

Product Name Levothyroxine Oral Solution (Advanz) – 25 mcg, 50mcg, 100mcg per 5 ml (Lactose Free)
Email medicalinformation@advanzpharma.com
Ingredients Levothyroxine sodium (each 5ml of oral solution contains levothyroxine equivalent to levothyroxine sodium anhydrous 25mcg, 50mcg or 100mcg), glycerol, citric acid monohydrate, sodium methyl parahydroxybenzoate (E219), sodium hydroxide, purified water
PIL https://tinyurl.com/wk4x8uw

  

Product Name Levothyroxine Oral Solution (Creo) – 25mcg, 50mcg, 100mcg, 125mcg per 5ml (Lactose Free)
Email pv@creopharma.com
Ingredients Levothyroxine sodium (each 5ml of oral solution contains levothyroxine equivalent to levothyroxine sodium anhydrous 25mcg, 50mcg, 100mcg or 125mcg), glycerol, citric acid anhydrous, sodium methyl parahydroxybenzoate (E219), citric acid 10%, purified wáter
PIL https://www.medicines.org.uk/emc/files/pil.10313.pdf

  

Product Name Levothyroxine Oral Solution (Teva) – 25mcg, 50mcg, 100mcg per 5ml (Lactose Free +)
Email medinfo@tevauk.com
Ingredients Levothyroxine sodium (each 5ml of oral solution contains levothyroxine equivalent to levothyroxine sodium anhydrous 25mcg, 50mcg or 100mcg), glycerol, citric acid monohydrate, sodium methyl parahydroxybenzoate (E219), sodium hydroxide, purified water
PIL https://tinyurl.com/tmqq3aa

 

Product Name Levothyroxine Oral Solution (Ten Pharma) – 25 mcg, 50mcg, 100mcg per 5 ml (Lactose Free)
Email medicalinformation@jensongroup.com
Ingredients Levothyroxine sodium (each 5 ml of oral solution contains levothyroxine equivalent to levothyroxine sodium 25mcg, 50mcg or 100mcg), glycerol, citric acid monohydrate, sodium methyl parahydroxybenzoate (E219), sodium propyl parahydroxybenzoate (E217), purified wáter
PIL 25mcg: https://tinyurl.com/vxbxfv6
50mcg: https://tinyurl.com/rxqjllc
100mcg: https://tinyurl.com/ww8tk32

 

Product Name Levothyroxine Oral Solution (Wockhardt) – 25mcg, 50 mcg, 100mcg per 5ml (Lactose Free)
Email Drug.Safety@wockhardt.co.uk
Ingredients Levothyroxine sodium (each 5ml of oral solution contains levothyroxine equivalent to levothyroxine sodium 25mcg, 50mcg or 100mcg), citric acid monohydrate, sodium methyl parahydroxybenzoate (E219), sodium propyl parahydroxybenzoate, propylene glycol, maltitol liquid, sodium hydroxide, hydrochloric acid, sodium hydroxide, purified wáter
PIL https://tinyurl.com/vsleb8d

 

Product Name Ethypharm Compounded Levothyroxine – Oral Suspension – various strengths and bottle sizes (Lactose Free)
Email connect@ethypharm.com
Ingredients Levothyroxine sodium, mannitol, xanthan gum, parabens, sorbitol syrup, saccharin sodium, ethanol, sterile water
Notes Doctor must write on the prescription the strength, quantity and which filler.  Pharmacist must hold an account with Ethypharm.

  

Product Name Ethypharm Compounded Levothyroxine –  Capsules – various strengths and pack sizes (Lactose Free +)
Email connect@ethypharm.com
Ingredients Levothyroxine sodium plus one filler (see below) – filler should be discussed with your doctor.
Notes All the capsules are gelatin capsules and may contain a variety of fillers (see below) although they may not all be available.
·    mannitol
·    calcium phosphate
·    calcium carbonate
·    lactose
·    avicel cellulose
·    calcium carbonate
Doctor must write on the prescription the strength, quantity and which filler.  Pharmacist must hold an account with Ethypharm.

  

Product Name Roseway Compounded Levothyroxine Thyroid Suspension (Lactose Free)
Email info@rosewaylabs.com
Ingredients Levothyroxine, almond oil, silica gel, cellulose, vitamin E acetate
Notes A prescription medication that must state strength per ml of T4. 30mls of medication will have the required dosage calibrated to a 1ml dose. The shelf life is 30 days and the medication does not need to be refrigerated

  

European Levothyroxine (not licensed in the UK)

 

Product Name L-Thyroxin (ALIUD ® PHARMA) – 50mcg, 100mcg Tablets (Lactose Free)
Email info@aliud.de
Ingredients Anhydrous levothyroxine sodium (each tablet contains either 50mcg or 100mcg of levothyroxine sodium), microcrystaline cellulose, magnesium stearate (vegetable origin), colloidal silicon dioxide, pre-gelatinised starch (from maize), talcum
Notes Obtainable by pharmacists holding an account with IDIS. PIL inside the box will be in German

 

Product Name L-Thyroxin, Henning (Sanofi-Aventis) – various strengths from 25mcg – 200mcg Tablets (Lactose Free)
Email medinfo.de@sanofi.com
Ingredients Levothyroxine sodium, corn starch, pre-gelatinised starch (maize), microcrystalline cellulose, sodium carbonate, sodium thiosulphate (Ph. Eur.), highly dispersed silica, hydrogenated castor oil
Notes This product is produced by the German branch but the UK company is very helpful (Tel: 01483 505515)
PIL https://tinyurl.com/wfpbgz9 (in German)

 

Product Name Euthyrox (Merck) – 25mcg, 50mcg, 75mcg, 88 mcg, 100mcg, 112mcg, 125mcg, 137mcg, 150mcg, 175mcg, 200mcg Tablets (Lactose Free)
Email medical.info.nl@merckgroup.com
Ingredients Levothyroxine sodium, citric acid anhydrous, corn starch, gelatin, magnesium stearate, mannitol, sodium croscarmellose
PIL https://www.drugs.com/pro/euthyrox.html

 

American Levothyroxine (not licensed in the UK)

  

Product Name Levothyroxine (Unithroid) –  various strengths between 25mcg – 300mcg Tablets
Email inquiries@jeromestevens.com  Distributor: info@gemini-labs.com
Ingredients Levothyroxine sodium, synthetic crystalline L-3,31,5,51 – tetraiodothyronine sodium salt [levothyroxine (T4) sodium], colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline cellulose, corn starch, acacia, sodium starch glycolate (See PIL for colouring information)
PIL https://tinyurl.com/ugj4f9y

  

Product Name Levothyroxine (Synthroid) –  various strengths between 25mcg – 300mcg Tablets
Email Contact form only on website
Website https://www.synthroid.com/
Ingredients Synthetic crystalline L-3,3′,5,5′- tetraiodothyronine sodium salt [levothyroxine (T4) sodium], acacia, confectioner’s sugar (contains corn starch), lactose monohydrate, magnesium stearate, povidone, talc (See PIL for colouring information)
PIL http://www.rxabbvie.com/pdf/synthroid.pdf

 

Product Name Levothyroxine (Tirosint) – various strengths from 13mcg – 200mcg Gel Capsules (Lactose Free)
Email info@akrimax.com
Ingredients Levothyroxine sodium, gelatin, glycerin, water
PIL https://tinyurl.com/rgrj9p3

  

Product Name Levothyroxine (Mylan) – various strengths between 25mcg – 300mcg Tablets (Lactose Free)
Email mguk_customer.services@mylan.co.uk
Ingredients Levothyroxine sodium, butylated hydroxyanisole, silicon dioxide, crospovidone, magnesium stearate, mannitol, microcrystalline cellulose, povidone, sodium lauryl sulfate, sucrose
PIL https://tinyurl.com/ula33fc

 

UK T3 (Liothyronine) Replacements

The half-life of T3 is one to two days, so you would get the maximum benefit of this after two to three days and the duration of effectiveness is up to three days after stopping T3.

 

Product Name Liothyronine (Tertroxin) (Advanz) – 20mcg Tablets
Email medicalinformation@advanzpharma.com
Ingredients

 

Liothyronine sodium, lactose, maize starch, acacia powder, sodium chloride, magnesium stearate, industrial methylated spirit, purified water
Comments This only comes in 20mcg tablets, which generally need to be cut in half or quartered for use with thyroxine
PIL https://tinyurl.com/s6dzo32

 

Product Name Roseway Compounded Liothyronine Thyroid Suspension (Lactose Free)
Email info@rosewaylabs.com
Ingredients Liothyronine, almond oil, silica gel, cellulose, vitamin E acetate
Notes A prescription medication that must state strength per ml of T3. 30mls of medication will have the required dosage calibrated to a 1ml dose. The shelf life is 30 days and the medication does not need to be refrigerated

 

Product Name Liothyronine (Teva) – 20mcg Tablets (Lactose Free)
Website www.tevauk.com
Email medinfo@tevauk.com
Ingredients Liothyronine sodium, microcrystalline cellulose, maize starch, pregelatinised starch, colloidal anhydrous silica, magnesium stearate
PIL https://tinyurl.com/surua9o

 

Product Name Liothyronine (Iraskin) (Morningside) – 5mcg, 10mcg, 20mcg Tablets
Email medicalenquiry@morningsidehealthcare.com
Ingredients Liothyronine sodium, lactose monohydrate, partially pregelatinised maize starch, spray dried acacia, sodium chloride, magnesium stearate
PIL https://tinyurl.com/vpczg5j

 

European T3 (Liothyronine) Replacements

 

Product Name Thybon, Hennings (Sanofi-Aventis) – 20mcg, 100mcg Tablets (Lactose Free)
Email medinfo.de@sanofi.com
Ingredients Liothyronine hydrochloride, pregelatinised starch (corn), corn starch, microcrystalline cellulose, sodium carbonates, sodium thiosulphate 5 H2O (Ph Eur), fumed silica, hydrogenated castor oil
PIL https://tinyurl.com/u462b8y (in German)

 

Product Name Slow Release T3 (compounded) (Lactose Free)
Email info@receptura.de
Ingredients Liothyronine, hydroxypropylmethyl cellulose. Capsule is made of cellulose.

  

Product Name Tiromel (Abdi Ibrahim) – 25mcg Tablets
Email info@abdiibrahim.com.tr
Ingredients Liothyronine sodium, lactose, polyvinylpyrrolidone, starch, magnesium stearate

  

Product Name Liotir Oral Solution (IBSA) – 5mcg (7 drops diluted in a little water), 10mcg, 15mcg, 20mcg
Email info@ibsa.it
Ingredients Liothyronine sodium, ethanol (96%), glycerol (85%)
PIL https://edoc.com/liotir

 

American T3 (Liothyronine) Replacements

  

Product Name Cytomel (King Pharmaceuticals) – 5mcg, 25mcg, 50mcg Tablets (Lactose Free)
Email http://www.pfizer.com/contact/contact_us_support
Website http://www.pfizer.com/
Ingredients Liothyronine sodium, calcium sulphate, gelatin, corn starch, stearic acid, sucrose, talc
Comments Comes in 5mcg tablets, which some people find much easier.
Pfizer have taken over King Pharmaceuticals.
Note: We have been unable to confirm if King Pharmaceuticals have a TSE certificate which is required for import into the UK
PIL http://labeling.pfizer.com/ShowLabeling.aspx?id=703

  

Product Name Liothyronine (Mylan) – 5mcg, 25mcg, 50mcg Tablets (Lactose Free)
Email mguk_customer.services@mylan.co.uk
Ingredients Liothyronine sodium, calcium sulfate anhydrous, gelatin, pregelatinized starch, stearic acid, sucrose, talc
PIL https://tinyurl.com/slrudgn

  

Product Name Liothyronine (Mayne Pharma) – 5mcg, 25mcg, 50mcg Tablets (Lactose Free)
Email maynepharma@dlss.com
Ingredients Liothyronine sodium, calcium sulfate, microcrystalline cellulose, hypromellose, talc, silicon dioxide
PIL https://tinyurl.com/wgdtrgp

   

Synthetic Combination Replacements

Not generally available on the NHS in the UK unless you can persuade your GP to prescribe on a “named patient” basis. These may be available from a private doctor (although they usually prefer the natural thyroid). This product would be a good idea for people who are allergic to pork and therefore who can’t take any of the natural thyroid hormones.

 

Product Name Roseway Compounded Levothyroxine plus Liothyronine Thyroid Suspension (Lactose Free)
Email info@rosewaylabs.com
Ingredients Levothyroxine, liothyronine, almond oil, silica gel, cellulose, vitamin E acetate
Notes A prescription medication that must state strength per ml of T4 and/or T3. 30mls of medication will have the required dosage calibrated to a 1ml dose. The shelf life is 30 days and the medication does not need to be refrigerated

 

European Brand (not licensed in the UK)

  

Product Name Novothyral (Merck Serono GmbH) – 75mcg, 100mcg Tablets
Email medicalpartner@merckserono.de
Manufacturers Merck KGaA, Frankfurter Straße 250, 64293 Darmstadt
Ingredients Levothyroxine Sodium (T4), Liothyronine Sodium (T3), Lactose Monohydrate, Maize Starch, Gelatin, Croscarmellose Sodium, Magnesium Stearate
Details 1 tablet Novothyral 75mcg contains 75mcg levothyroxine sodium and 15mcg liothyronine sodium
1 tablet Novothyral 100mcg contains 100mcg levothyroxine sodium and 20 mcg liothyronine sodium
PIL https://tinyurl.com/rlg9vtp

   

Natural Thyroid Hormone Replacements

  

Product Name Armour Thyroid – various strengths from 15mg (¼ grain) – 300mg (5 grains) Tablets (Lactose Free)
Email Not known
Website www.allergan.com/products/key-products/product-prescribing
Ingredients Thyroid tablets, USP (38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) per 60mg (1 grain) of thyroid), calcium stearate, dextrose, microcrystalline cellulose, sodium starch glycolate, opadry white
Details Armour contains approximately 38mcg T4 and 9mcg T3 plus an X factor (something not yet understood). This means that patients taking Armour Thyroid are automatically getting T3 immediately into the system
PIL https://www.allergan.com/assets/pdf/armourthyroid_pi

 

Product Name Nature-Throid® – various strengths from 16.25 mg (¼ grain) – 325mg (5 grains) Tablets
Email http://getrealthyroid.com/get-real-now/contact-us/
Ingredients Thyroid USP, colloidal silicon dioxide, dicalcium phosphate, lactose monohydrate*, magnesium stearate, microcrystalline cellulose, croscarmellose sodium, stearic acid, opadry II 85F19316 clear.
* Present in traceable amount as part of Thyroid USP (diluent).
Details Nature-Throid® (Thyroid USP) tablets, micro-coated, easy to swallow with a reduced odour, for oral use are natural preparations derived from porcine thyroid glands (T3 liothyronine is approximately four times as potent as T4 levothyroxine on a microgram for microgram basis). They provide 38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) for each 65 mg (1 Grain) of the labelled content of thyroid
PIL https://getrealthyroid.com/assets/docs/Nature-Throid-Prescribing-Information.pdf

  

Product Name WP Thyroid – various strengths from 16.25 mg
(¼ grain) – 130mg (2 grains) Tablets
Email http://getrealthyroid.com/get-real-now/contact-us/
Ingredients Thyroid USP, inulin, medium chain triglycerides, lactose monohydrate*
*Present in traceable amount as part of Thyroid USP (diluent)
Details WP Thyroid tablets are natural preparations derived from porcine thyroid glands. (T3 liothryonine is approximately four times as potent as T4 levothyroxine on a microgram for microgram basis.) They provide 38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) for each 65 mg (1 Grain) of the labelled content of thyroid
PIL https://getrealthyroid.com/assets/docs/WP-Thyroid-Prescribing-Information.pdf

  

Product Name NP Thyroid – 30mg, 60mg, 90mg, 120mg Tablets (Lactose Free)
Email npthyroid@acellapharma.com.
Ingredients 38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) per grain of thyroid (or per 60 mg of the labelled amount of thyroid), calcium stearate, dextrose (agglomerated), mineral oil
PIL https://npthyroid.com/wp-content/uploads/2018/03/AC-015_NPThyroid_WebPI.pdf

  

Product Name THYROID® – 30mg, 60mg, 125mg Tablets
Email General Questions: info@ECI2012.net
Medical Questions: psq@ECI2012.net
Ingredients Thyroid tablets, USP (35 mcg levothyroxine (T4) and 8 mcg liothyronine (T3) per 60mg (1 grain) of thyroid), desiccated thyroid containing lactose, derived from porcine thyroid glands, cornstarch, magnesium stearate, sugar, talc
Details Gluten, paraben, sulfite and tartrazine free
PIL http://eci2012.net/wp-content/uploads/2015/11/Thyroid-Product-Monograph-En-PCR-15-084.pdf

 

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Date updated: 09/04/20 (V2.2)
Review date:  05/03/21